EBOO therapy costs $1,500 per session at Nexsis BioHealth in Brickell, Miami. A typical course runs 3 to 6 sessions spaced one to two weeks apart, which puts a full protocol between $4,500 and $9,000. Package pricing is available and is quoted after your physician consultation. No US health insurer covers EBOO, so it is a self-pay treatment.
That is the short answer. The longer answer is worth reading, because EBOO pricing varies more between clinics than almost any other therapy in regenerative medicine, and the gap is not arbitrary. What follows is what the number covers, what moves it up or down, and how to think about the total cost of a course rather than the sticker price of one visit.
A single EBOO session at our Brickell clinic is $1,500. That price includes the physician consultation that precedes treatment, the single-use filter and sterile consumables, the anticoagulant, the roughly 80 minutes of clinical chair time, and physician supervision from start to finish.
Most patients are not booking one session. EBOO is protocol-based, and the recommendation after consultation is usually 3 to 6 sessions spaced one to two weeks apart. At the single-session rate that is $4,500 for a three-session course and $9,000 for six.
Package pricing brings the per-session figure down, and we quote it after the consultation rather than before. That is deliberate. Until a physician has reviewed your history and goals, nobody can honestly tell you whether you need three sessions or six, and quoting a package before that point means quoting a treatment plan nobody has designed yet.
One more lever worth knowing about: our membership program starts at $149 per month and includes 15 to 20 percent off all services. Applied to a $1,500 session that is roughly $1,200 to $1,275 per visit, which changes the arithmetic meaningfully on a six-session course. Whether it makes sense depends on what else you are using at the clinic.
EBOO is expensive relative to other ozone modalities for structural reasons, not positioning ones. Five things account for most of the cost.
The filter. EBOO runs your blood through a single-use dialysis-style membrane filter. It is discarded after one patient, every time. This is the largest consumable cost in the procedure and it is the main reason EBOO prices sit well above major autohemotherapy, which uses a simple bag and treats a fraction of the blood volume.
Chair time. A session is approximately 80 minutes of continuous extracorporeal circulation, with a clinician present throughout. That is a long block of staffed clinical time for a single patient.
The equipment. A clinical-grade closed-loop EBOO machine is a significant capital item, and its cost is amortized across the sessions a clinic runs.
Sterile consumables and anticoagulant. Two IV catheters, tubing sets, and the anticoagulant that keeps blood moving through the circuit are per-session costs that do not scale away.
Screening and medical review. EBOO is not a walk-in service. The physician consultation, history review and candidacy assessment are clinical labor built into the price.
When you see EBOO advertised well below the market rate, one of these five is usually being trimmed. It is a fair question to ask any clinic directly: what filter do you use, is it single-use, and who is in the room during the session.
Almost nobody gets a durable result from one EBOO session, and reputable clinics say so. The therapy is designed around a course. If your goal is to try it once and decide, a single session is a reasonable way to see how you tolerate the procedure, but it is not a fair test of whether the protocol works for you.
Across the US market, multi-session packages typically run 20 to 40 percent below the cumulative single-session rate. That discount exists because the clinic can plan the schedule, order consumables in volume, and reduce the administrative overhead of booking each visit separately.
The practical approach: go to the consultation with the question "how many sessions do you actually recommend for my situation, and what does that total." A clinic that cannot answer the first half of that question should not be answering the second half either.
EBOO pricing in the United States spans a wide band. There is no national fee schedule, no insurance reimbursement rate anchoring the market, and no requirement that clinics price consistently. Here is roughly how the tiers break down.
| Tier | Typical single session | What it usually reflects |
|---|---|---|
| Budget or introductory | $700 to $900 | Promotional first-session rate, or a lower-cost filter and consumable setup. Often a limited-time offer rather than the standing price. |
| Market standard | $1,000 to $1,500 | Single-use filter, full session length, physician-supervised. The range most established US clinics sit in. |
| Major-metro and concierge | $1,500 to $2,500 | Higher-cost markets, extended protocols, or bundled labs and adjunct therapies. |
| Nexsis BioHealth, Brickell Miami | $1,500 | Physician consultation included, single-use filter, approximately 80-minute session, physician-supervised throughout. |
Miami sits in the upper half of the national range, which is what you would expect from a major metro with high clinical real estate and staffing costs. Within Miami specifically, the meaningful comparison is not price alone but what is included and who is supervising.
No. No major US health insurer covers EBOO, and that is unlikely to change in the near term.
The reason is regulatory. Under 21 CFR 801.415, the FDA's position is that ozone is "a toxic gas with no known useful medical application in specific, adjunctive, or preventive therapy." EBOO is therefore not an FDA-approved treatment in the United States, and treatments without FDA approval for a given indication are not reimbursed.
We would rather tell you this plainly than let you discover it at the billing desk. EBOO is a self-pay wellness therapy. There is no insurance claim to file, no prior authorization to chase, and no reimbursement to expect. Some patients are able to use HSA or FSA funds depending on their plan administrator's rules, which is worth asking your administrator about directly rather than assuming either way.
The practical upside of self-pay is price transparency. You know the number before you book, and there is no surprise balance bill afterward.
Nexsis BioHealth is a physician-led regenerative medicine clinic at 40 SW 13th St in Brickell, Miami, serving patients from Downtown Miami, Coral Gables, Coconut Grove and Miami Beach. EBOO here is performed under physician supervision, with medical oversight from Dr. Alvaro J. Ocampo, a pathologist and environmental medicine physician whose focus includes anti-aging and hormone therapy. The clinic has been practicing regenerative medicine since 2018.
A session runs as follows. You meet with a physician who reviews your medical history, current concerns and treatment goals, and determines whether EBOO is appropriate for you at all. If you proceed, an IV catheter is placed in each arm. Blood is drawn from one arm and passed through a clinical-grade EBOO machine, where it is filtered, infused with medical-grade ozone and re-oxygenated before being returned through the other arm in a continuous closed loop. The full session takes approximately 80 minutes.
Patients come to us for EBOO with chronic fatigue, autoimmune conditions, Lyme disease, long COVID, cardiovascular concerns, joint pain and metabolic dysfunction, as well as for general wellness optimization. EBOO is not a treatment for acute illness, it is not a substitute for care you are receiving elsewhere, and it is not appropriate for everyone. That determination is made in consultation, not on a website.
Some patients combine EBOO with IV therapy or hyperbaric oxygen therapy as part of a broader protocol. Whether that is worth the additional cost is a clinical question, and the honest answer for some patients is no.
You are entitled to know what you are paying for, so here is the state of the research without embellishment.
The most cited controlled trial of EBOO comes from Di Paolo and colleagues, published in the International Journal of Artificial Organs in 2005. Twenty-eight patients with peripheral artery disease were randomized to receive either EBOO or intravenous prostacyclin. Patients treated with EBOO showed significantly greater regression of skin lesions than the comparison group, along with improvements in pain, itching, heaviness in the legs and general well-being. Across 210 EBOO treatments, no side effects or complications were recorded.
Two caveats belong alongside that result. The trial found no significant difference in lower-limb vascularisation in either group, meaning the mechanism behind the improvement was not the one the researchers expected. And 28 patients is a small trial in one indication, published two decades ago. It is real evidence, and it is not the same thing as a body of evidence.
For most of the reasons patients seek EBOO in Miami today, including fatigue, long COVID and general wellness, the human trial data is thin. Anyone telling you otherwise is selling. That does not make EBOO worthless, and it does not make $1,500 unreasonable for a filtered, physician-supervised extracorporeal procedure. It does mean you should price it as an option you are choosing with clear eyes, not as an established standard of care.
Work backwards from the protocol, not the session. Three practical steps.
If the total is more than you want to commit to, say so at the consultation. A shorter initial course with a decision point partway through is a legitimate option, and it is a better outcome than starting a six-session protocol you abandon after two.
The consultation is where the real number gets set, because the real number depends on the protocol and the protocol depends on you. If you want to understand what EBOO would cost in your situation, book a consultation with our physician team in Brickell. You can also read the full treatment detail on our EBOO therapy page.
We will tell you what we recommend, what it totals, and whether we think EBOO is the right route for you at all. Sometimes it is not, and we would rather say that at the consultation than after you have paid for a course.
At Nexsis BioHealth in Brickell, a single EBOO session is $1,500. Across the US, single sessions typically range from about $900 to $2,500 depending on the market and what is included. Miami pricing generally sits in the upper half of that range, in line with other major metros.
Most protocols run 3 to 6 sessions spaced one to two weeks apart. At standing rates that is $4,500 to $9,000 for a full course. Package pricing reduces the per-session cost and is quoted after your physician consultation, once the recommended session count is established.
No. No major US health insurer covers EBOO, because ozone is not FDA-approved for this use under 21 CFR 801.415. It is a self-pay treatment with no claim to file. Some patients can use HSA or FSA funds, which depends entirely on your plan administrator's rules, so ask them directly.
EBOO uses a single-use dialysis-style filter and processes blood continuously in a closed loop for roughly 80 minutes, with a clinician present throughout. Major autohemotherapy treats a small volume of blood in a bag in a fraction of the time, with far lower consumable costs. The price difference reflects the filter, the equipment and the staffed clinical time.
Introductory or promotional rates around $700 to $900 exist, but they are usually first-session offers rather than standing prices. Before booking on price alone, ask what filter is used, whether it is single-use, how long the session runs, and who supervises it. A lower price that reflects a shorter session or a reused component is not the same treatment.
At Nexsis BioHealth the $1,500 session price includes the physician consultation, the single-use filter, sterile consumables, anticoagulant and physician supervision throughout. Any baseline labs your physician orders are separate and will be discussed at consultation so there are no surprises.
The strongest controlled evidence is a 2005 randomized trial of 28 patients with peripheral artery disease, which found significantly greater regression of skin lesions with EBOO than with intravenous prostacyclin, and no complications across 210 treatments. For most other indications, including fatigue and long COVID, human trial data is limited. EBOO is not FDA-approved, and we describe it to patients as an option chosen with full information rather than an established standard of care.
