EBOO therapy, short for Extracorporeal Blood Oxygenation and Ozonation, is a procedure in which your blood is drawn through an IV line, passed through a filter, exposed to medical-grade ozone and oxygen, and returned to your body through a second IV line in a continuous closed loop. At Nexsis BioHealth in Brickell, Miami, a session takes about 80 minutes, runs under physician supervision, and is typically done as a series of 3 to 6 sessions.
That is the short answer. If you have seen EBOO mentioned on a podcast, in a longevity forum or on a friend's Instagram story, you probably have more questions than that paragraph answers: what actually happens to your blood, how it differs from other ozone treatments, who it suits, who should avoid it, and what the research really says. This guide walks through all of it in plain English, the way our physicians explain it to patients at their first consultation.
EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. Each word describes part of the process. Extracorporeal means outside the body. Oxygenation means adding oxygen. Ozonation means exposing something to ozone, a molecule made of three oxygen atoms rather than the two in the oxygen you breathe.
Put together, EBOO is a treatment in which your blood is treated outside your body and then returned. The defining feature is that it happens continuously. Blood leaves through one arm, travels through the machine and filter, and comes back through the other arm, over and over, for the length of the session.
EBOO works by circulating your blood through a closed-loop device that does three things in sequence: it filters the blood, exposes it to a controlled mixture of ozone and oxygen, and returns it to your bloodstream. The whole circuit is sealed, so blood never touches open air.
The equipment is the important part. Your blood passes through a single-use, dialysis-style membrane filter. That filter is the reason EBOO looks and costs very different from simpler ozone methods. It is discarded after every patient, every session. An anticoagulant keeps blood moving smoothly through the tubing so it does not clot inside the circuit.
The ozone itself is generated by medical equipment and dosed in a controlled concentration. The idea behind ozone therapy is that a brief, controlled exposure acts as a mild stressor that the body responds to, and that this response is where the proposed benefits come from. That mechanism is still being studied, which we cover honestly in the evidence section below.
A session at our Brickell clinic follows the same four steps every time, and the full appointment takes roughly 80 minutes of treatment time plus a short setup.
Before your first session, a physician reviews your medical history, current medications and what you are hoping to change. This is also where we decide whether EBOO is appropriate for you at all. Some people are better served by a different treatment, and we would rather say so up front.
A clinician places a small IV catheter in each arm. One line draws blood out. The other returns it. Most patients describe this as the most noticeable part of the appointment, and it feels much like having blood drawn.
Blood flows from one arm into the machine, through the filter, through the ozone and oxygen exposure, and back into the other arm. You sit in a treatment chair for this part. Most patients read, work on a phone or rest. The clinical team monitors you and the equipment continuously.
When the session ends, the lines are removed and the IV sites are dressed. Most patients return to normal activity the same day. We recommend eating beforehand, staying well hydrated, and planning a lighter afternoon after your first session until you know how you respond.
One EBOO session at Nexsis BioHealth takes approximately 80 minutes. Most protocols call for 3 to 6 sessions spaced one to two weeks apart, so a full course usually runs between three weeks and three months.
The right number depends on your goals and how you respond, which is why we set the session count at consultation rather than selling a fixed package to everyone. Some patients do an initial series and then return for occasional maintenance sessions. Others complete one series and stop. A good protocol includes a review point partway through, so you are not committing to six sessions before you know whether the treatment suits you.
EBOO is the most intensive of the common ozone methods, because it treats blood continuously for over an hour rather than treating a single bag of blood or working through the skin. Here is how the three treatments people most often compare it with stack up.
| EBOO | Major Autohemotherapy (MAH) | Ozone sauna | |
|---|---|---|---|
| How it works | Blood circulates continuously through a filter and ozone exposure, then returns | A single bag of blood is drawn, mixed with ozone, then reinfused | Ozone is applied to the skin inside a steam cabinet; no blood is drawn |
| Blood treated | Continuous flow over the full session | One bag, typically a few hundred milliliters at most | None |
| Filtration | Yes, single-use membrane filter | No | No |
| IV lines | Two, one in each arm | One | None |
| Session time | About 80 minutes | Usually under an hour | Usually under an hour |
| Relative cost | Highest, driven by the filter and staffed chair time | Moderate | Lowest |
The practical takeaway: EBOO is not simply a stronger version of MAH. It is a different procedure with filtration added, more equipment involved and a much longer staffed session. That difference is the main reason it costs more, which we break down in detail in our guide to how much EBOO therapy costs in Miami.
Patients come to our Brickell clinic asking about EBOO for a fairly consistent set of reasons:
It is worth being precise about what this list means. These are the reasons people seek EBOO, not a list of conditions EBOO has been proven to treat. That distinction matters, and it is the subject of the next section.
The honest answer is that EBOO has a small evidence base, with one notable controlled trial and a much larger body of clinical experience and early research. Anyone telling you it is proven for fatigue, long COVID or anti-aging is overstating the science.
The most cited controlled study was published by Di Paolo and colleagues in 2005 in the International Journal of Artificial Organs. Twenty-eight patients with peripheral artery disease were randomized to EBOO or to an intravenous comparison drug. The EBOO group showed significantly greater healing of skin lesions, along with improvements in pain and general well-being, and no complications were recorded across 210 EBOO treatments.
That result is genuinely encouraging, and it is also limited. It was a small trial, in one condition, published two decades ago. It does not tell us how well EBOO works for the reasons most people seek it today.
Regulation is part of the picture too. The FDA's long-standing position, set out in federal regulation 21 CFR 801.415, is that ozone has no known useful medical application. EBOO is therefore not an FDA-approved treatment in the United States, and no insurer covers it.
So where does that leave you? EBOO is best understood as a physician-supervised wellness therapy chosen with clear eyes, not as an established standard of care. Some patients report meaningful improvements in energy and well-being. Others notice little. A responsible clinic tells you that before you start, and builds in a review point so you can judge for yourself.
When it is performed by trained clinicians using clinical-grade equipment and a single-use filter, EBOO is generally well tolerated. In the controlled trial described above, no complications were recorded across 210 treatments. Safety depends heavily on screening, equipment and supervision, which is why those three things are where clinics differ most.
The side effects patients most commonly notice are mild and short-lived:
Anything beyond that should be reported to the clinical team right away. That is part of why every session at our clinic is supervised from start to finish rather than left to run unattended.
EBOO is not appropriate for everyone, and screening is the most important safety step in the whole process. Conditions physicians commonly screen for before any ozone therapy include:
This is not a complete list, and it is not a substitute for a medical review. It is the reason the first step at Nexsis is always a physician consultation, not a booking form.
Preparation is simple, and it makes the session noticeably more comfortable:
EBOO therapy at Nexsis BioHealth is $1,500 per session, which includes the physician consultation, the single-use filter, sterile consumables and physician supervision throughout. A full course of 3 to 6 sessions therefore runs $4,500 to $9,000 at the single-session rate, with package pricing quoted after consultation. Members of our membership program receive 15 to 20 percent off. For the full breakdown, see our guide to EBOO therapy cost in Miami.
Yes, and many patients do. The most common pairings at our clinic are IV therapy, for hydration and nutrient support, and hyperbaric oxygen therapy, for patients focused on oxygen delivery and recovery. Whether a combination is worth the extra cost is a clinical question, and for some patients the honest answer is no. Your physician will tell you which, if any, make sense for your goals.
Nexsis BioHealth is a physician-led regenerative medicine clinic at 40 SW 13th St in Brickell, Miami. EBOO is performed here under physician supervision using clinical-grade equipment and a single-use filter for every patient. We see patients from Downtown Miami, Coral Gables, Coconut Grove, Key Biscayne and Miami Beach.
EBOO is not a treatment for acute illness, it does not replace care you are receiving elsewhere, and it is not right for everyone. The way to find out whether it fits your situation is a consultation. Book a consultation with our physician team, or read the full service details on our EBOO therapy page.
EBOO is a treatment where your blood is drawn through an IV, filtered, exposed to medical-grade ozone and oxygen, and returned through a second IV in a continuous loop. At Nexsis BioHealth in Brickell, a session takes about 80 minutes and is supervised by a physician throughout.
Most patients find it comfortable. The main sensation is the IV placement in each arm, which feels similar to having blood drawn. During the session itself, most people read, use their phone or rest. Some feel tired afterward, particularly after the first session.
Standard ozone IV methods, such as major autohemotherapy, treat a single bag of blood and reinfuse it. EBOO circulates blood continuously through a filter and ozone exposure for the full session, using two IV lines and a single-use membrane filter. It is a longer, more equipment-intensive procedure.
Most protocols run 3 to 6 sessions spaced one to two weeks apart. The right number depends on your goals and how you respond, so your physician sets it at consultation and reviews progress partway through rather than committing you to a fixed package.
No. The FDA's position under 21 CFR 801.415 is that ozone has no known useful medical application, so EBOO is not an FDA-approved treatment in the United States. It is offered as a physician-supervised wellness therapy, and insurance does not cover it.
The most common side effects are mild: bruising at the IV sites, tiredness after a session, occasional lightheadedness and minor vein irritation. Eating and hydrating beforehand helps. Anything more significant should be reported to the clinical team right away.
People who are commonly screened out include those with G6PD deficiency, pregnancy, bleeding or clotting disorders, uncontrolled hyperthyroidism, severe anemia, low platelets, or a recent heart attack or stroke. A physician consultation is required before any session.
At Nexsis BioHealth in Brickell, EBOO is $1,500 per session, including the physician consultation, single-use filter and supervision. A full course of 3 to 6 sessions runs $4,500 to $9,000 at standing rates, with package pricing and member discounts available.
This article is for general education and is not medical advice. EBOO is not FDA approved. Treatment decisions at Nexsis BioHealth are made by our licensed physician team after consultation and medical review.
